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Rab10 Antibody

Purified Mouse Monoclonal Antibody

  • WB - Rab10 Antibody AO1432a
    Figure 1: Western blot analysis using Rab10 mouse mAb against Hela (1) and NIH/3T3 (2) cell lysate.
  • IF - Rab10 Antibody AO1432a
    Figure 2: Immunofluorescence analysis of LOVO cells using Rab10 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P61026
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Clone Names 4E2
Isotype IgG1
Calculated MW 22.5kDa
Description RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking.
Immunogen Purified recombinant fragment of human Rab10 expressed in E. Coli.

Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 10890
Other Names Ras-related protein Rab-10, RAB10
Dilution WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRab10 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RAB10
Function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane. In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response. Plays also a specific role in asymmetric protein transport to the plasma membrane within the polarized neuron and epithelial cells. In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane while in epithelial cells, it regulates transport from the Golgi to the basolateral membrane. Moreover, may play a role in the basolateral recycling pathway and in phagosome maturation. According to PubMed:23263280, may play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion.
Cellular Location Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane. Endosome membrane. Recycling endosome membrane. Cytoplasmic vesicle, phagosome membrane. Cell projection, cilium Endoplasmic reticulum membrane. Note=Associates with SLC2A4/GLUT4 storage vesicles. Localizes to the base of the cilium. Transiently associates with phagosomes (By similarity). According to PubMed:23263280 localizes to the endoplasmic reticulum at domains of new tubule growth.
Research Areas
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1. Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6508-12. 2. J Biol Chem. 2003 Apr 25;278(17):15373-80. 3. Mol Med. 2010 Jul-Aug;16(7-8):247-53.

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$ 325.00
Cat# AO1432a
(40 western blots)
Availability: 7-10 days
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