|Application ||WB, ICC, E|
|Description||This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency.|
|Immunogen||Purified recombinant fragment of human MATN1 expressed in E. Coli.|
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Other Names||S-adenosylmethionine synthase isoform type-1, AdoMet synthase 1, 188.8.131.52, Methionine adenosyltransferase 1, MAT 1, Methionine adenosyltransferase I/III, MAT-I/III, MAT1A, AMS1, MATA1|
|Dilution||WB~~1/500 - 1/2000|
IF~~1/200 - 1/1000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MATN1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.|
|Tissue Location||Expressed in liver.|
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Provided below are standard protocols that you may find useful for product applications.
1. Biochem J. 1993 Jul 15;293 ( Pt 2):481-6. 2. Am J Hum Genet. 1997 Mar;60(3):540-6. 3. Am J Hum Genet. 2000 Feb;66(2):347-55.
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