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EIF2AK3 Antibody

Purified Mouse Monoclonal Antibody

  • WB - EIF2AK3 Antibody AO1467a
    Figure 1: Western blot analysis using EIF2AK3 mAb against HEK293 (1) and EIF2AK3(AA: 929-1116)-hIgGFc transfected HEK293 (2) cell lysate.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NZJ5
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 5G5
Isotype IgG1
Calculated MW 125kDa
Description The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.
Immunogen Purified recombinant fragment of human EIF2AK3 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 9451
Other Names Eukaryotic translation initiation factor 2-alpha kinase 3,, PRKR-like endoplasmic reticulum kinase, Pancreatic eIF2-alpha kinase, HsPEK, EIF2AK3, PEK, PERK
Dilution WB~~1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsEIF2AK3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EIF2AK3
Synonyms PEK, PERK
Function Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function (By similarity).
Cellular Location Endoplasmic reticulum membrane; Single-pass type I membrane protein
Tissue Location Ubiquitous. A high level expression is seen in secretory tissues
Research Areas
Citations (0)

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1. Autophagy. 2008 Apr 1;4(3):364-7. 2. J Biol Chem. 2008 Jun 20;283(25):17020-9. 3. Hum Mol Genet. 2008 Oct 15;17(20):3254-62.

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$ 325.00
Cat# AO1467a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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