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TAB2 Antibody

Purified Mouse Monoclonal Antibody

     
  • WB - TAB2 Antibody AO1475a
    Figure 1: Western blot analysis using TAB2 mAb against HEK293 (1) and TAB2(AA: 1-300)-hIgGFc transfected HEK293 (2) cell lysate.
  • FC - TAB2 Antibody AO1475a
    Figure 2: Flow cytometric analysis of HL-60 cells using TAB2 mouse mAb (green) and negative control (purple).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, E
Primary Accession Q9NYJ8
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 3B5
Isotype IgG1
Calculated MW 80kDa
Description The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.
Immunogen Purified recombinant fragment of human TAB2 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 23118
Other Names TGF-beta-activated kinase 1 and MAP3K7-binding protein 2, Mitogen-activated protein kinase kinase kinase 7-interacting protein 2, TAK1-binding protein 2, TAB-2, TGF-beta-activated kinase 1-binding protein 2, TAB2, KIAA0733, MAP3K7IP2
Dilution WB~~1/500 - 1/2000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTAB2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TAB2
Synonyms KIAA0733, MAP3K7IP2
Function Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'- linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development.
Cellular Location Membrane; Peripheral membrane protein Cytoplasm, cytosol. Note=Following IL1 stimulation, translocation occurs from the membrane to cytosol
Tissue Location Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves.
Research Areas
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References

1. J Clin Endocrinol Metab. 2006 Mar;91(3):1056-61. 2. Sci STKE. 2006 Oct 17;2006(357):re13. 3. Am J Hum Genet. 2010 Jun 11;86(6):839-49.

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$ 325.00
Cat# AO1475a
Size:
Quantity:
(40 western blots)
Availability: 7-10 days
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