|Application ||WB, ICC, E|
|Description||This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. (Provided by RefSeq) SUZ12 is overexpressed in several human tumors, including tumors of the colon, breast and liver.Tissue specificity: Overexpressed in breast and colon cancer.|
|Immunogen||Purified recombinant fragment of human SUZ12 expressed in E. Coli.|
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Other Names||Polycomb protein SUZ12, Chromatin precipitated E2F target 9 protein, ChET 9 protein, Joined to JAZF1 protein, Suppressor of zeste 12 protein homolog, SUZ12, CHET9, JJAZ1, KIAA0160|
|Dilution||WB~~1/500 - 1/2000|
IF~~1/200 - 1/1000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SUZ12 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CHET9, JJAZ1, KIAA0160|
|Function||Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.|
|Tissue Location||Overexpressed in breast and colon cancer.|
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1. Genes Dev. 2008 May 15;22(10):1345-55. 2. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):20001-6.
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