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SUZ12 Antibody

Purified Mouse Monoclonal Antibody

  • WB - SUZ12 Antibody AO1494a
    Figure 1: Western blot analysis using SUZ12 mAb against HEK293 (1) and SUZ12(AA: 533-739)-hIgGFc transfected HEK293 (2) cell lysate.
  • IF - SUZ12 Antibody AO1494a
    Figure 2: Immunofluorescence analysis of U251 cells using SUZ12 mouse mAb (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
  • IF - SUZ12 Antibody AO1494a
    Figure 3: Immunofluorescence analysis of MCF-7 cells using SUZ12 mouse mAb (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q15022
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2C11
Isotype IgG1
Calculated MW 83.1kDa
Description This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. (Provided by RefSeq) SUZ12 is overexpressed in several human tumors, including tumors of the colon, breast and liver.Tissue specificity: Overexpressed in breast and colon cancer.
Immunogen Purified recombinant fragment of human SUZ12 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 23512
Other Names Polycomb protein SUZ12, Chromatin precipitated E2F target 9 protein, ChET 9 protein, Joined to JAZF1 protein, Suppressor of zeste 12 protein homolog, SUZ12, CHET9, JJAZ1, KIAA0160
Dilution WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSUZ12 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SUZ12
Synonyms CHET9, JJAZ1, KIAA0160
Function Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
Cellular Location Nucleus.
Tissue Location Overexpressed in breast and colon cancer.
Research Areas
Citations (0)

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1. Genes Dev. 2008 May 15;22(10):1345-55. 2. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):20001-6.

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$ 325.00
Cat# AO1494a
(40 western blots)
Availability: 7-10 days
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