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E7 Antibody

Purified Mouse Monoclonal Antibody

  • E - E7 Antibody AO1531a

    Red: Control Antigen (100ng);
    Purple: Antigen (10ng);
    Green: Antigen (50ng);
    Blue: Antigen (100ng);

  • WB - E7 Antibody AO1531a
    Figure 1: Western blot analysis using E7 mAb against human E7 (AA: 1-98) recombinant protein.
  • IHC - E7 Antibody AO1531a
    Figure 2: Immunohistochemical analysis of paraffin-embedded placenta tissues (left) and ovarian cancer (right) using E7 mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P03129
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 6F3
Isotype IgG1
Calculated MW 21kDa
Description E7 transforming protein (Human papillomavirus type 16).
Immunogen Purified recombinant fragment of E7 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 1489079
Other Names Protein E7, E7
Dilution E~~1/10000
WB~~1/500 - 1/2000
IHC~~1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsE7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name E7
Function E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription (By similarity).
Research Areas
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1. Methods Mol Med. 2005;119:363-79. 2. Viral Immunol. 2006 Summer;19(3):468-80.

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$ 385.00
Cat# AO1531a
(40 western blots)
Availability: 7-10 days
Bulk Size
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