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COVID19
>   home   >   Products   >   Primary Antibodies   >   Immunology   >   E7 Antibody   

E7 Antibody

Purified Mouse Monoclonal Antibody

     
  • E - E7 Antibody AO1531a

    Red: Control Antigen (100ng);
    Purple: Antigen (10ng);
    Green: Antigen (50ng);
    Blue: Antigen (100ng);

    detail
  • WB - E7 Antibody AO1531a
    Figure 1: Western blot analysis using E7 mAb against human E7 (AA: 1-98) recombinant protein.
    detail
  • IHC - E7 Antibody AO1531a
    Figure 2: Immunohistochemical analysis of paraffin-embedded placenta tissues (left) and ovarian cancer (right) using E7 mouse mAb with DAB staining.
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, E
Primary Accession P03129
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 6F3
Isotype IgG1
Calculated MW 21kDa
Description E7 transforming protein (Human papillomavirus type 16).
Immunogen Purified recombinant fragment of E7 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 1489079
Other Names Protein E7, E7
Dilution E~~1/10000
WB~~1/500 - 1/2000
IHC~~1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsE7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name E7 {ECO:0000255|HAMAP-Rule:MF_04004}
Function Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
Cellular Location Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04004, ECO:0000269|PubMed:18996550, ECO:0000269|PubMed:3033296}. Host nucleus {ECO:0000255|HAMAP-Rule:MF_04004, ECO:0000269|PubMed:18996550} Note=Predominantly found in the host nucleus. {ECO:0000255|HAMAP- Rule:MF_04004, ECO:0000269|PubMed:18996550}
Research Areas
Citations (0)
citation

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References

1. Methods Mol Med. 2005;119:363-79. 2. Viral Immunol. 2006 Summer;19(3):468-80.

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$ 385.00
Cat# AO1531a
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