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GRK2 Antibody
Purified Mouse Monoclonal Antibody
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- BACKGROUND
Application 
| WB, IHC, ICC, E |
|---|---|
| Primary Accession | P25098 |
| Reactivity | Human, Mouse, Rat, Monkey |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 3F8 |
| Isotype | IgG1 |
| Calculated MW | 80kDa |
| Description | The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. (provided by RefSeq)Tissue specificity: Expressed in peripheral blood leukocytes |
| Immunogen | Purified recombinant fragment of human GRK2 expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
| Gene ID | 156 |
|---|---|
| Other Names | Beta-adrenergic receptor kinase 1, Beta-ARK-1, 2.7.11.15, G-protein coupled receptor kinase 2, ADRBK1, BARK, BARK1, GRK2 |
| Dilution | E~~1/10000 WB~~1/500 - 1/2000 IHC~~1/500 - 1/2000 IF~~1/200 - 1/1000 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GRK2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GRK2 (HGNC:289) |
|---|---|
| Synonyms | ADRBK1, BARK, BARK1 |
| Function | Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (PubMed:19715378). Key regulator of LPAR1 signaling (PubMed:19306925). Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (PubMed:19306925). Desensitizes LPAR1 and LPAR2 in a phosphorylation- independent manner (PubMed:19306925). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity). Inhibits relaxation of airway smooth muscle in response to blue light (PubMed:30284927). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P26817}. Cell membrane {ECO:0000250|UniProtKB:P21146}. Postsynapse {ECO:0000250|UniProtKB:P26817}. Presynapse {ECO:0000250|UniProtKB:P26817} |
| Tissue Location | Expressed in peripheral blood leukocytes. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1. Mol Biol Cell. 2008 Jul;19(7):2973-83. 2. Biochemistry. 2009 May 26;48(20):4285-93.
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$ 385.00
Cat# AO1550a
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