|Application ||WB, IHC, E|
|Description||The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.|
|Immunogen||Purified recombinant fragment of human MTHFR expressed in E. Coli. |
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Other Names||Methylenetetrahydrofolate reductase, 18.104.22.168, MTHFR|
WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MTHFR Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine.|
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Provided below are standard protocols that you may find useful for product applications.
1. Kardiol Pol. 2008 Dec;66(12):1269-77. 2. Arq Bras Endocrinol Metabol. 2008 Nov;52(8):1374-81.
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