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CRK Antibody
Purified Mouse Monoclonal Antibody
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- CITATIONS
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- BACKGROUND
Application 
| WB, IHC, FC, ICC, E |
|---|---|
| Primary Accession | P46108 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 3G11E8 |
| Isotype | IgG2b |
| Calculated MW | 42kDa |
| Description | This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. |
| Immunogen | Purified recombinant fragment of human CRK expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
| Gene ID | 1398 |
|---|---|
| Other Names | Adapter molecule crk, Proto-oncogene c-Crk, p38, CRK |
| Dilution | E~~1/10000 WB~~1/500 - 1/2000 IHC~~1/200 - 1/1000 IF~~1/200 - 1/1000 FC~~1/200 - 1/400 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CRK Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CRK |
|---|---|
| Function | Involved in cell branching and adhesion mediated by BCAR1- CRK-RAPGEF1 signaling and activation of RAP1. |
| Cellular Location | Cytoplasm. Cell membrane. Note=Translocated to the plasma membrane upon cell adhesion. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1. Seikagaku. 2009 May;81(5):361-76. 2. Mol Cancer Res. 2009 Sep;7(9):1582-92.
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$ 385.00
Cat# AO1607a
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