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JUP Antibody

Purified Mouse Monoclonal Antibody

  • E - JUP Antibody AO1620a

    Red: Control Antigen (100ng);
    Purple: Antigen (10ng);
    Green: Antigen (50ng);
    Blue: Antigen (100ng);

  • WB - JUP Antibody AO1620a
    Figure 1: Western blot analysis using JUP mAb against human JUP (AA: 534-740) recombinant protein. (Expected MW is 48.5 kDa)
  • WB - JUP Antibody AO1620a
    Figure 2: Western blot analysis using JUP mouse mAb against T47D (1), MCF-7 (2), SKBR-3 (3), A431 (4) and HEK293 (5) cell lysate.
  • IHC - JUP Antibody AO1620a
    Figure 3: Immunohistochemical analysis of paraffin-embedded rectum tissues using JUP mouse mAb with DAB staining.
  • IHC - JUP Antibody AO1620a
    Figure 4: Immunohistochemical analysis of paraffin-embedded stomach cancer tissues using JUP mouse mAb with DAB staining.
  • IF - JUP Antibody AO1620a
    Figure 5: Immunofluorescence analysis of U251 cells using JUP mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P14923
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 4C12
Isotype IgG1
Calculated MW 82kDa
Description This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described.
Immunogen Purified recombinant fragment of human JUP expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 3728
Other Names Junction plakoglobin, Catenin gamma, Desmoplakin III, Desmoplakin-3, JUP, CTNNG, DP3
Dilution E~~1/10000
WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
IF~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsJUP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name JUP
Synonyms CTNNG, DP3
Function Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).
Cellular Location Cell junction, adherens junction. Cell junction, desmosome. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Cytoplasmic in a soluble and membrane-associated form
Research Areas
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1. Cell. 2009 Jul 23;138(2):389-403. 2. Cancer Res. 2009 Jul 15;69(14):5734-42. 

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$ 385.00
Cat# AO1620a
(40 western blots)
Availability: 7-10 days
Bulk Size
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