|Application ||WB, ICC, E|
|Description||The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined.|
|Immunogen||Purified recombinant fragment of human HFE expressed in E. Coli. |
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Other Names||Hereditary hemochromatosis protein, HLA-H, HFE, HLAH|
WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HFE Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in all tissues tested except brain.|
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Provided below are standard protocols that you may find useful for product applications.
1. Respir Med. 2009 Dec;103(12):1866-70. 2. Clin J Am Soc Nephrol. 2009 Aug;4(8):1331-7.
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