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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MAP3K2 Antibody   

MAP3K2 Antibody

Purified Mouse Monoclonal Antibody

  • E - MAP3K2 Antibody AO1623a

    Red: Control Antigen (100ng);
    Purple: Antigen (10ng);
    Green: Antigen (50ng);
    Blue: Antigen (100ng);

  • WB - MAP3K2 Antibody AO1623a
    Figure 1: Western blot analysis using MAP3K2 mAb against human MAP3K2 (AA: 148-359) recombinant protein. (Expected MW is 49.2 kDa)
  • WB - MAP3K2 Antibody AO1623a
    Figure 2: Western blot analysis using MAP3K2 mAb against HEK293 (1) and MAP3K2(AA: 148-359)--hIgGFc transfected HEK293 (2) cell lysate.
  • IF - MAP3K2 Antibody AO1623a
    Figure 3: Immunofluorescence analysis of 3T3-L1 cells using MAP3K2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y2U5
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 4B4
Isotype IgG1
Calculated MW 70kDa
Description The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process.
Immunogen Purified recombinant fragment of human MAP3K2 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 10746
Other Names Mitogen-activated protein kinase kinase kinase 2,, MAPK/ERK kinase kinase 2, MEK kinase 2, MEKK 2, MAP3K2, MAPKKK2, MEKK2
Dilution E~~1/10000
WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMAP3K2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAP3K2
Synonyms MAPKKK2, MEKK2
Function Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.
Cellular Location Cytoplasm. Nucleus. Note=Upon EGF stimulation, translocates into the nucleus
Research Areas
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1. Clin Cancer Res. 2009 Sep 1;15(17):5541-51.  2. J Biol Chem. 2009 May 15;284(20):13533-41.

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$ 385.00
Cat# AO1623a
(40 western blots)
Availability: 7-10 days
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