|Application ||WB, IHC, E|
|Description||The protein encoded by this gene is a member of kinesin-like protein family. This family of proteins are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests its essential role in metaphase chromosome alignment and maintenance.|
|Immunogen||Purified recombinant fragment of human KID expressed in E. Coli. |
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Other Names||Kinesin-like protein KIF22, Kinesin-like DNA-binding protein, Kinesin-like protein 4, KIF22, KID, KNSL4|
WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KID Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity). Plays a role in congression of laterally attached chromosomes in NDC80- depleted cells (PubMed:25743205).|
|Cellular Location||Nucleus. Cytoplasm, cytoskeleton|
|Tissue Location||Expressed in bone, cartilage, joint capsule, ligament, skin, and primary cultured chondrocytes|
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1. Cell. 2008 Mar 7;132(5):771-82. 2. Retrovirology. 2009 May 19;6:47.
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