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TNNI2 Antibody

Purified Mouse Monoclonal Antibody

  • E - TNNI2 Antibody AO1626a

    Red: Control Antigen (100ng);
    Purple: Antigen (10ng);
    Green: Antigen (50ng);
    Blue: Antigen (100ng);

  • WB - TNNI2 Antibody AO1626a
    Figure 1: Western blot analysis using TNNI2 mAb against human TNNI2 (AA: 1-182) recombinant protein. (Expected MW is 46.8 kDa)
  • WB - TNNI2 Antibody AO1626a
    Figure 2: Western blot analysis using TNNI2 mAb against HEK293 (1) and TNNI2(AA: 1-182)-hIgGFc transfected HEK293 (2) cell lysate.
  • IHC - TNNI2 Antibody AO1626a
    Figure 3: Immunohistochemical analysis of paraffin-embedded rabbit cardiac muscle tissues using TNNI2 mouse mAb with DAB staining.
  • IHC - TNNI2 Antibody AO1626a
    Figure 4: Immunohistochemical analysis of paraffin-embedded cardiac muscle tissues using TNNI2 mouse mAb with DAB staining.
  • IHC - TNNI2 Antibody AO1626a
    Figure 5: Immunohistochemical analysis of paraffin-embedded striated muscle tissues using TNNI2 mouse mAb with DAB staining.
  • FC - TNNI2 Antibody AO1626a
    Figure 6: Flow cytometric analysis of NIH/3T3 cells using TNNI2 mouse mAb (blue) and negative control (red).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P48788
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2F12A11
Isotype IgG1
Calculated MW 21kDa
Description This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene.
Immunogen Purified recombinant fragment of human TNNI2 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 7136
Other Names Troponin I, fast skeletal muscle, Troponin I, fast-twitch isoform, TNNI2
Dilution E~~1/10000
WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTNNI2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNNI2
Function Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Research Areas
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1. Am J Hum Genet. 2009 Nov;85(5):628-42. 2. Cell Motil Cytoskeleton. 2008 Aug;65(8):652-61.

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$ 385.00
Cat# AO1626a
(40 western blots)
Availability: 7-10 days
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