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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   NQO1 Antibody   

NQO1 Antibody

Purified Mouse Monoclonal Antibody

  • E - NQO1 Antibody AO1642a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - NQO1 Antibody AO1642a
    Figure 1: Western blot analysis using NQO1 mAb against human NQO1 (AA: 134-274) recombinant protein. (Expected MW is 41.3 kDa)

  • WB - NQO1 Antibody AO1642a
    Figure 2: Western blot analysis using NQO1 mouse mAb against A549 (1), SKNES (2), HepG2 (3), MCF-7 (4) and Hela (5) cell lysate.
  • IHC - NQO1 Antibody AO1642a
    Figure 3: Immunohistochemical analysis of paraffin-embedded testis tissues using NQO1 mouse mAb with DAB staining.
  • IHC - NQO1 Antibody AO1642a
    Figure 4: Immunohistochemical analysis of paraffin-embedded ovarian cancer tissues using NQO1 mouse mAb with DAB staining.
  • FC - NQO1 Antibody AO1642a
    Figure 5: Flow cytometric analysis of NIH/3T3 cells using NQO1 mouse mAb (green) and negative control (red).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P15559
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 4D12
Isotype IgG1
Calculated MW 31kDa
Description This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Immunogen Purified recombinant fragment of human NQO1 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 1728
Other Names NAD(P)H dehydrogenase [quinone] 1,, Azoreductase, DT-diaphorase, DTD, Menadione reductase, NAD(P)H:quinone oxidoreductase 1, Phylloquinone reductase, Quinone reductase 1, QR1, NQO1, DIA4, NMOR1
Dilution E~~1/10000
WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNQO1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NQO1
Synonyms DIA4, NMOR1
Function The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
Cellular Location Cytoplasm.
Research Areas
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1. Mol Cancer Ther. 2009 Dec;8(12):3369-78. 2. J Biol Chem. 2009 Nov 27;284(48):33233-41.

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$ 385.00
Cat# AO1642a
(40 western blots)
Availability: 7-10 days
Bulk Size
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