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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   KCNQ1 Antibody   

KCNQ1 Antibody

Purified Mouse Monoclonal Antibody

  • E - KCNQ1 Antibody AO1647a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - KCNQ1 Antibody AO1647a
    Figure 1: Western blot analysis using KCNQ1 mAb against human KCNQ1 (AA: 229-347) recombinant protein. (Expected MW is 74.7 kDa)
  • WB - KCNQ1 Antibody AO1647a
    Figure 2: Western blot analysis using KCNQ1 mouse mAb against MCF-7 (1) and A431 (2) cell lysate.
  • FC - KCNQ1 Antibody AO1647a
    Figure 3: Flow cytometric analysis of MCF-7 cells using KCNQ1 mouse mAb (green) and negative control (red).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P51787
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 5E12
Isotype IgG2b
Calculated MW 95kDa
Description This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene. 
Immunogen Purified recombinant fragment of human KCNQ1 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 3784
Other Names Potassium voltage-gated channel subfamily KQT member 1, IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1, KQT-like 1, Voltage-gated potassium channel subunit Kv7.1, KCNQ1, KCNA8, KCNA9, KVLQT1
Dilution E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKCNQ1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KCNQ1
Synonyms KCNA8, KCNA9, KVLQT1
Function Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea.
Cellular Location Cell membrane; Multi-pass membrane protein Cytoplasmic vesicle membrane; Multi- pass membrane protein
Tissue Location Abundantly expressed in heart, pancreas, prostate, kidney, small intestine and peripheral blood leukocytes Less abundant in placenta, lung, spleen, colon, thymus, testis and ovaries
Research Areas
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1. Biochem Biophys Res Commun. 2009 May 29;383(2):206-9.  2. J Biol Chem. 2009 Jun 12;284(24):16452-62. 

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$ 385.00
Cat# AO1647a
(40 western blots)
Availability: 7-10 days
Bulk Size
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