TUBA8 Antibody
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, FC, ICC, E |
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Primary Accession | Q9NY65 |
Reactivity | Human, Rat |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 2D6 |
Isotype | IgG2b |
Calculated MW | 50kDa |
Description | This gene encodes a member of the alpha tubulin protein family. Alpha tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Mutations in this gene are associated with polymicrogyria and optic nerve hypoplasia. Alternate splicing results in multiple transcript variants. |
Immunogen | Purified recombinant fragment of human TUBA8 expressed in E. Coli. |
Formulation | Ascitic fluid containing 0.03% sodium azide. |
Gene ID | 51807 |
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Dilution | E~~1/10000 WB~~1/500 - 1/2000 IHC~~1/200 - 1/1000 IF~~1/200 - 1/1000 FC~~1/200 - 1/400 |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | TUBA8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TUBA8 |
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Synonyms | TUBAL2 |
Function | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
Cellular Location | Cytoplasm, cytoskeleton. |
Tissue Location | Preferentially expressed in heart, skeletal muscle and testis. Expressed at low levels in the developing brain. Expressed in megakaryocytes and platelets (PubMed:34704371) |
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Provided below are standard protocols that you may find useful for product applications.
References
1. Am J Hum Genet. 2009 Nov;85(5):737-44. 2. Am J Hum Genet. 2009 Nov;85(5):628-42.
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