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COTL1 Antibody
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q14019 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 5C8E3 |
| Isotype | IgG1 |
| Calculated MW | 16kDa |
| Description | This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. |
| Immunogen | Purified recombinant fragment of human COTL1 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Gene ID | 23406 |
|---|---|
| Other Names | Coactosin-like protein, COTL1, CLP |
| Dilution | E~~1/10000 WB~~1/500 - 1/2000 FC~~1/200 - 1/400 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | COTL1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | COTL1 |
|---|---|
| Synonyms | CLP |
| Function | Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis. |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton. Nucleus |
| Tissue Location | Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1. Biochem J. 2009 Dec 14;425(1):265-74. 2. Exp Mol Med. 2009 May 31;41(5):354-61.
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$ 385.00
Cat# AO1672a
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