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ITGA4 Antibody

Purified Mouse Monoclonal Antibody

  • E - ITGA4 Antibody AO1695a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - ITGA4 Antibody AO1695a
    Figure 1: Western blot analysis using ITGA4 mAb against human ITGA4 (AA: 926-978) recombinant protein. (Expected MW is 31.7 kDa)
  • WB - ITGA4 Antibody AO1695a
    Figure 2: Western blot analysis using ITGA4 mouse mAb against K562(1) and Jurkat (2) cell lysate.
  • FC - ITGA4 Antibody AO1695a
    Figure 3: Flow cytometric analysis of Jurkat cells using ITGA4 mouse mAb (green) and negative control (red).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P13612
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 5C4
Isotype IgG1
Calculated MW 115kDa
Description The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain.
Immunogen Purified recombinant fragment of human ITGA4 expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 3676
Other Names Integrin alpha-4, CD49 antigen-like family member D, Integrin alpha-IV, VLA-4 subunit alpha, CD49d, ITGA4, CD49D
Dilution E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsITGA4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ITGA4
Synonyms CD49D
Function Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
Cellular Location Membrane; Single-pass type I membrane protein
Research Areas
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Clin Immunol. 2009 Jun;131(3):472-80. Am J Med Genet B Neuropsychiatr Genet. 2009 Dec 5;150B(8):1147-51.

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$ 385.00
Cat# AO1695a
(40 western blots)
Availability: 7-10 days
Bulk Size
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