|Application ||WB, IHC, FC, E|
|Description||The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants.|
|Immunogen||Purified recombinant fragment of human HAS3 expressed in E. Coli. |
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Other Names||Hyaluronan synthase 3, 220.127.116.11, Hyaluronate synthase 3, Hyaluronic acid synthase 3, HA synthase 3, HAS3|
WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
FC~~1/200 - 1/400
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HAS3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction (By similarity).|
|Cellular Location||Membrane; Multi-pass membrane protein|
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BMC Cancer. 2009 May 12;9:143. BMC Cancer. 2010 Sep 27;10:512.
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