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FOS Antibody

Purified Mouse Monoclonal Antibody

  • E - FOS Antibody AO1710a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - FOS Antibody AO1710a
    Figure 1: Western blot analysis using FOS mAb against human FOS (AA: 116-298) recombinant protein. (Expected MW is 45.8 kDa)
  • WB - FOS Antibody AO1710a
    Figure 2: Western blot analysis using FOS mouse mAb against HeLa (1), and HeLa (2) cell lysate.
  • IHC - FOS Antibody AO1710a
    Figure 3: Immunohistochemical analysis of paraffin-embedded colon cancer tissues using FOS mouse mAb with DAB staining.
  • IHC - FOS Antibody AO1710a
    Figure 4: Immunohistochemical analysis of paraffin-embedded cerebellum tissues using FOS mouse mAb with DAB staining.
  • FC - FOS Antibody AO1710a
    Figure 5: Flow cytometric analysis of HeLa cells using FOS mouse mAb (green) and negative control (red).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P01100
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2G2
Isotype IgG1
Calculated MW 40.7kDa
Description The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death.
Immunogen Purified recombinant fragment of human FOS expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 2353
Other Names Proto-oncogene c-Fos, Cellular oncogene fos, G0/G1 switch regulatory protein 7, FOS, G0S7
Dilution E~~1/10000
WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFOS Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FOS
Synonyms G0S7
Function Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD- binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.
Cellular Location Nucleus. Endoplasmic reticulum. Cytoplasm, cytosol. Note=In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30
Research Areas
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Mol Cell Biochem. 2010 Apr;337(1-2):53-63. Cancer Invest. 2009 Oct;27(8):816-24.

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$ 385.00
Cat# AO1710a
(40 western blots)
Availability: 7-10 days
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