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GRIA2 Antibody

Purified Mouse Monoclonal Antibody

  • E - GRIA2 Antibody AO1732a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - GRIA2 Antibody AO1732a
    Figure 1: Western blot analysis using GRIA2 mAb against human GRIA2 recombinant protein. (Expected MW is 43 kDa)
  • WB - GRIA2 Antibody AO1732a
    Figure 2: Western blot analysis using GRIA2 mAb against HEK293 (1) and GRIA2 (AA: 652-807)-hIgGFc transfected HEK293 (2) cell lysate.
  • WB - GRIA2 Antibody AO1732a
    Figure 3: Western blot analysis using GRIA2 mouse mAb against HeLa (1) cell lysate.
  • FC - GRIA2 Antibody AO1732a
    Figure 4: Flow cytometric analysis of SK-N-SH cells using GRIA2 mouse mAb (green) and negative control (red).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P19491
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 7G6
Isotype IgG1
Calculated MW 98.8kDa
Description Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (Q/R and R/G), which is thought to render the channels impermeable to Ca(2+), and to affect the kinetic aspects of these channels in rat brain. Alternative splicing, resulting in transcript variants encoding different isoforms (flip and flop), has been noted for this gene.
Immunogen Purified recombinant fragment of human GRIA2 (AA: 652-807) expressed in E. Coli.

Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 29627
Other Names Glutamate receptor 2, GluR-2, AMPA-selective glutamate receptor 2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, GluA2, Gria2, Glur2
Dilution E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGRIA2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Gria2
Synonyms Glur2
Function Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
Cellular Location Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression
Tissue Location Detected in forebrain. Detected in dendrites of neuronal cells.
Research Areas
Citations (0)

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1.Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010 Feb;24(4):173-6. 2.Neurosci Lett. 2011 Jun 15;497(1):42-5.

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$ 385.00
Cat# AO1732a
(40 western blots)
Availability: 7-10 days
Bulk Size
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