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TGFb1 Antibody

Purified Mouse Monoclonal Antibody

  • E - TGFb1 Antibody AO1733a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - TGFb1 Antibody AO1733a
    Figure 1: Western blot analysis using TGFb1 mAb against human TGFb1 recombinant protein. (Expected MW is 41 kDa)
  • IHC - TGFb1 Antibody AO1733a
    Figure 2: Immunohistochemical analysis of paraffin-embedded lung cancer tissues using TGFb1 mouse mAb with DAB staining.
  • IHC - TGFb1 Antibody AO1733a
    Figure 3: Immunohistochemical analysis of paraffin-embedded lymphoid tissue tissues using TGFb1 mouse mAb with DAB staining.
  • FC - TGFb1 Antibody AO1733a
    Figure 4: Flow cytometric analysis of A549 cells using TGFb1 mouse mAb (green) and negative control (red).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P01137
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 7F6
Isotype IgG1
Calculated MW 44.3kDa
Description This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease
Immunogen Purified recombinant fragment of human TGFb1 (AA: 62-195) expressed in E. Coli.

Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 7040
Other Names Transforming growth factor beta-1, TGF-beta-1, Latency-associated peptide, LAP, TGFB1, TGFB
Dilution E~~1/10000
WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTGFb1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TGFB1
Synonyms TGFB
Function Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T- helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells.
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Highly expressed in bone. Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage.
Research Areas
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1.Cell. 2011 Oct 28;147(3):565-76. 2.Kobe J Med Sci. 2011 May 11;56(6):E242-52.

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$ 385.00
Cat# AO1733a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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