|Application ||WB, IHC, FC, ICC, E|
|Description||This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1.|
|Immunogen||Purified recombinant fragment of human TWF1 (AA: 335-384 ) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Other Names||Twinfilin-1, Protein A6, Protein tyrosine kinase 9, TWF1, PTK9|
WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
FC~~1/200 - 1/400
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TWF1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity).|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Note=Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts (By similarity).|
|Tissue Location||Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower levels in the brain, bladder and heart. Not detected in liver|
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Provided below are standard protocols that you may find useful for product applications.
1.Cancer Epidemiol Biomarkers Prev. 2010 May;19(5):1356-61.2.Cancer Epidemiol Biomarkers Prev. 2009 May;18(5):1651-8.
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