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PTPN11 Antibody

Purified Mouse Monoclonal Antibody

  • E - PTPN11 Antibody AO1758a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - PTPN11 Antibody AO1758a
    Figure 1: Western blot analysis using PTPN11 mAb against human PTPN11 recombinant protein. (Expected MW is 33.4 kDa)
  • IF - PTPN11 Antibody AO1758a
    Figure 2: Immunofluorescence analysis of HeLa cells using PTPN11 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
  • FC - PTPN11 Antibody AO1758a
    Figure 3: Flow cytometric analysis of HepG2 cells using PTPN11 mouse mAb (green) and negative control (red).
  • IHC - PTPN11 Antibody AO1758a
    Figure 4: Immunohistochemical analysis of paraffin-embedded breast cancer tissues using PTPN11 mouse mAb with DAB staining.
  • IHC - PTPN11 Antibody AO1758a
    Figure 5: Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using PTPN11 mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q06124
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 6D9
Isotype IgG1
Calculated MW 68.4kDa
Description The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.
Immunogen Purified recombinant fragment of human PTPN11 (AA: 263-329) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 5781
Other Names Tyrosine-protein phosphatase non-receptor type 11,, Protein-tyrosine phosphatase 1D, PTP-1D, Protein-tyrosine phosphatase 2C, PTP-2C, SH-PTP2, SHP-2, Shp2, SH-PTP3, PTPN11, PTP2C, SHPTP2
Dilution E~~1/10000
WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPTPN11 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTPN11
Synonyms PTP2C, SHPTP2
Function Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.
Cellular Location Cytoplasm.
Tissue Location Widely expressed, with highest levels in heart, brain, and skeletal muscle.
Research Areas
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1.Blood. 2011 Aug 11;118(6):1504-15.2.Cancer Cell. 2011 May 17;19(5):629-39.

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$ 385.00
Cat# AO1758a
(40 western blots)
Availability: 7-10 days
Bulk Size
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