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TRIP6 Antibody

Purified Mouse Monoclonal Antibody

  • E - TRIP6 Antibody AO1771a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - TRIP6 Antibody AO1771a
    Figure 1: Western blot analysis using TRIP6 mAb against human TRIP6 recombinant protein. (Expected MW is 44.4 kDa)
  • WB - TRIP6 Antibody AO1771a
    Figure 2: Western blot analysis using TRIP6 mouse mAb against K562 and A431 (2) cell lysate.
  • FC - TRIP6 Antibody AO1771a
    Figure 3: Flow cytometric analysis of K562 cells using TRIP6 mouse mAb (green) and negative control (red).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q15654
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 6H4
Isotype IgG1
Calculated MW 50.3kDa
Description This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Immunogen Purified recombinant fragment of human TRIP6 (AA: 107-291) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 7205
Other Names Thyroid receptor-interacting protein 6, TR-interacting protein 6, TRIP-6, Opa-interacting protein 1, OIP-1, Zyxin-related protein 1, ZRP-1, TRIP6, OIP1
Dilution E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTRIP6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIP6
Synonyms OIP1
Function Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.
Cellular Location Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus. Cytoplasm. Note=Shuttles between nucleus and cytoplasm
Tissue Location Abundantly expressed in kidney, liver and lung. Lower levels in heart, placenta and pancreas. Expressed in colonic epithelial cells. Up-regulated in colonic tumors
Research Areas
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1.Biol Cell. 2011 Dec 1;103(12):573-91. 2.Mol Cell Biol. 2010 Dec;30(23):5582-96.

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$ 385.00
Cat# AO1771a
(40 western blots)
Availability: 7-10 days
Bulk Size
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