|Application ||WB, FC, E|
|Description||This gene belongs to the NPY family and it encodes a protein that is synthesized as a 95 aa polypeptide precursor in the pancreatic islets of Langerhans. It is cleaved into two peptide products; the active hormone of 36 aa and an icosapeptide of unknown function. The hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain.|
|Immunogen||Purified recombinant fragment of human PPY (AA: 1-95) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Other Names||Pancreatic prohormone, Pancreatic polypeptide, PP, Obinepitide, Pancreatic hormone, PH, Pancreatic icosapeptide, PI, PPY, PNP|
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PPY Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.|
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1.Am J Clin Nutr. 2011 Oct;94(4):967-72. 2.Pharm Res. 2012 Jun;29(6):1698-711.
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