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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CAMK4 Antibody   

CAMK4 Antibody

Purified Mouse Monoclonal Antibody

  • E - CAMK4 Antibody AO1785a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - CAMK4 Antibody AO1785a
    Figure 1: Western blot analysis using CAMK4 mAb against human CAMK4 recombinant protein. (Expected MW is 54.8 kDa)
  • WB - CAMK4 Antibody AO1785a
    Figure 2: Western blot analysis using CAMK4 mAb against HEK293 (1) and CAMK4 (AA: 35-292)-hIgGFc transfected HEK293 (2) cell lysate.
  • WB - CAMK4 Antibody AO1785a
    Figure 3: Western blot analysis using CAMK4 mouse mAb against Jurkat (1), SK-N-SH (2), Raji (3), and HeLa (4) cell lysate.
  • IF - CAMK4 Antibody AO1785a
    Figure 3: Immunofluorescence analysis of HepG2 cells using CAMK4 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
  • IHC - CAMK4 Antibody AO1785a
    Figure 6: Immunohistochemical analysis of paraffin-embedded ovarian cancer tissues using CAMK4 mouse mAb with DAB staining.
  • IHC - CAMK4 Antibody AO1785a
    Figure 7: Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using CAMK4 mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q16566
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 8C5B8
Isotype IgG1
Calculated MW 58kDa
Description The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells.
Immunogen Purified recombinant fragment of human CAMK4 (AA: 35-292 ) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 814
Other Names Calcium/calmodulin-dependent protein kinase type IV, CaMK IV,, CaM kinase-GR, CAMK4, CAMK, CAMK-GR, CAMKIV
Dilution E~~1/10000
WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCAMK4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CAMK4
Function Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.
Cellular Location Cytoplasm. Nucleus. Note=Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix (By similarity).
Tissue Location Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue
Research Areas
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1.J Biol Chem. 2009 Aug 7;284(32):21327-37. 2.Rejuvenation Res. 2011 Jun;14(3):283-91.

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$ 385.00
Cat# AO1785a
(40 western blots)
Availability: 7-10 days
Bulk Size
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