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MESP2 Antibody

Purified Mouse Monoclonal Antibody

  • E - MESP2 Antibody AO1789a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - MESP2 Antibody AO1789a
    Figure 1: Western blot analysis using MESP2 mAb against human MESP2 recombinant protein. (Expected MW is 31.4 kDa)
  • WB - MESP2 Antibody AO1789a
    Figure 2: Western blot analysis using MESP2 mAb against HEK293 (1) and MESP2 (AA: 37-94)-hIgGFc transfected HEK293 (2) cell lysate.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q0VG99
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1B3F9
Isotype IgG1
Calculated MW 41.8kDa
Description This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02).
Immunogen Purified recombinant fragment of human MESP2 (AA: 37-94 ) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 145873
Other Names Mesoderm posterior protein 2, Class C basic helix-loop-helix protein 6, bHLHc6, MESP2, BHLHC6, SCDO2
Dilution E~~1/10000
WB~~1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMESP2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MESP2
Synonyms BHLHC6, SCDO2
Function Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981}
Research Areas
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The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is activated by ADP. ;


1.Stud Health Technol Inform. 2012;176:52-5. 2.Am J Hum Genet. 2008 Jun;82(6):1334-41.

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$ 385.00
Cat# AO1789a
(40 western blots)
Availability: 7-10 days
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