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PHC1 Antibody

Purified Mouse Monoclonal Antibody

  • E - PHC1 Antibody AO1803a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - PHC1 Antibody AO1803a
    Figure 1: Western blot analysis using PHC1 mAb against human PHC1 recombinant protein. (Expected MW is 52.8 kDa)
  • WB - PHC1 Antibody AO1803a
    Figure 2: Western blot analysis using PHC1 mAb against HEK293 (1) and PHC1 (AA: 758-1004)-hIgGFc transfected HEK293 (2) cell lysate.
  • FC - PHC1 Antibody AO1803a
    Figure 3: Flow cytometric analysis of HEK293 cells using PHC1 mouse mAb (green) and negative control (red).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P78364
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1F3F3
Isotype IgG1
Calculated MW 105.5kDa
Description This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein.
Immunogen Purified recombinant fragment of human PHC1 (AA: 758-1004) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 1911
Other Names Polyhomeotic-like protein 1, hPH1, Early development regulatory protein 1, PHC1, EDR1, PH1
Dilution E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPHC1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PHC1
Synonyms EDR1, PH1
Function Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression.
Cellular Location Nucleus
Research Areas
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1.Development. 2007 Feb;134(3):579-90. 2.Nature. 2006 May 18;441(7091):349-53.

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$ 385.00
Cat# AO1803a
(40 western blots)
Availability: 7-10 days
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