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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SLC27A2 Antibody   

SLC27A2 Antibody

Purified Mouse Monoclonal Antibody

  • E - SLC27A2 Antibody AO1828a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - SLC27A2 Antibody AO1828a
    Figure 1: Western blot analysis using SLC27A2 mAb against human SLC27A2 recombinant protein. (Expected MW is 32.4 kDa)
  • WB - SLC27A2 Antibody AO1828a
    Figure 2: Western blot analysis using SLC27A2 mAb against HEK293 (1) and SLC27A2 (AA: 346-405)-hIgGFc transfected HEK293 (2) cell lysate.
  • IHC - SLC27A2 Antibody AO1828a
    Figure 3: Immunohistochemical analysis of paraffin-embedded liver cancer tissues using SLC27A2 mouse mAb with DAB staining.
  • IHC - SLC27A2 Antibody AO1828a
    Figure 4: Immunohistochemical analysis of paraffin-embedded esophageal cancer tissues using SLC27A2 mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O14975
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 6B3A9
Isotype IgG1
Calculated MW 70.3kDa
Description The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very-long-chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic reticulum and peroxisomes, but not in mitochondria. Its decreased peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Immunogen Purified recombinant fragment of human SLC27A2 (AA: 346-405) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 11001
Other Names Very long-chain acyl-CoA synthetase, VLACS, VLCS, 6.2.1.-, Fatty acid transport protein 2, FATP-2, Fatty-acid-coenzyme A ligase, very long-chain 1, Long-chain-fatty-acid--CoA ligase,, Solute carrier family 27 member 2, THCA-CoA ligase, Very long-chain-fatty-acid-CoA ligase, SLC27A2, ACSVL1, FACVL1, FATP2, VLACS
Dilution E~~1/10000
WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSLC27A2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC27A2
Function Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity).
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Peroxisome membrane; Multi-pass membrane protein. Note=Peripheral membrane associated with the lumenal side of peroxisomes
Tissue Location Expressed in liver, kidney, placenta and pancreas.
Research Areas
Citations (0)

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The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms. ; ;


1. PLoS One. 2011;6(10):e25865. 2. Eur J Cancer. 2011 Feb;47(3):420-7.

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$ 385.00
Cat# AO1828a
(40 western blots)
Availability: 7-10 days
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