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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SERPINA7 Antibody   

SERPINA7 Antibody

Purified Mouse Monoclonal Antibody

     
  • E - SERPINA7 Antibody AO1857a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - SERPINA7 Antibody AO1857a
    Figure 1: Western blot analysis using SERPINA7 mAb against human SERPINA7 recombinant protein. (Expected MW is 41.4 kDa)
  • WB - SERPINA7 Antibody AO1857a
    Figure 2: Western blot analysis using SERPINA7 mAb against HEK293 (1) and SERPINA7 (AA: 168-302)-hIgGFc transfected HEK293 (2) cell lysate.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P05543
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1C3H11
Isotype IgG1
Calculated MW 46.3kDa
Description There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.
Immunogen Purified recombinant fragment of human SERPINA7 (AA: 168-302) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 6906
Other Names Thyroxine-binding globulin, Serpin A7, T4-binding globulin, SERPINA7, TBG
Dilution E~~1/10000
WB~~1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSERPINA7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SERPINA7
Synonyms TBG
Function Major thyroid hormone transport protein in serum.
Cellular Location Secreted.
Tissue Location Expressed by the liver and secreted in plasma.
Research Areas
Citations (0)

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Background

There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined. ;

References

1. Gene. 2012 Sep 15;506(2):289-94. 2. Endocr Regul. 2010 Apr;44(2):43-7.

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$ 385.00
Cat# AO1857a
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