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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   DIS3L2 Antibody   

DIS3L2 Antibody

Purified Mouse Monoclonal Antibody

  • E - DIS3L2 Antibody AO1864a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - DIS3L2 Antibody AO1864a
    Figure 1: Western blot analysis using DIS3L2 mAb against human DIS3L2 recombinant protein. (Expected MW is 50.2 kDa)
  • WB - DIS3L2 Antibody AO1864a
    Figure 2: Western blot analysis using DIS3L2 mAb against HEK293 (1) and DIS3L2 (AA: 27-250)-hIgGFc transfected HEK293 (2) cell lysate.
  • WB - DIS3L2 Antibody AO1864a
    Figure 3: Western blot analysis using DIS3L2 mouse mAb against Hela (1) and HepG2 (2) cell lysate.
  • FC - DIS3L2 Antibody AO1864a
    Figure 4: Flow cytometric analysis of Jurkat cells using DIS3L2 mouse mAb (green) and negative control (red).
  • IHC - DIS3L2 Antibody AO1864a
    Figure 5: Immunohistochemical analysis of paraffin-embedded endometrial cancer tissues using DIS3L2 mouse mAb with DAB staining.
  • IHC - DIS3L2 Antibody AO1864a
    Figure 6: Immunohistochemical analysis of paraffin-embedded bladder cancer tissues using DIS3L2 mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8IYB7
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 6C7B2
Isotype IgG1
Calculated MW 99.3kDa
Description The protein encoded by this gene is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene.
Immunogen Purified recombinant fragment of human DIS3L2 (AA: 27-250) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 129563
Other Names DIS3-like exonuclease 2 {ECO:0000255|HAMAP-Rule:MF_03045}, hDIS3L2, 3.1.13.- {ECO:0000255|HAMAP-Rule:MF_03045}, DIS3L2 {ECO:0000255|HAMAP-Rule:MF_03045}, FAM6A
Dilution E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDIS3L2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DIS3L2 {ECO:0000255|HAMAP-Rule:MF_03045}
Synonyms FAM6A
Function 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.
Cellular Location Cytoplasm. Cytoplasm, P-body
Research Areas
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The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. ;


1. Nat Rev Mol Cell Biol. 2013 Jun;14(6):328. 2. Nat Genet. 2012 Feb 5;44(3):277-84.

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$ 385.00
Cat# AO1864a
(40 western blots)
Availability: 7-10 days
Bulk Size
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