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DIS3L2 Antibody
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, FC, E |
|---|---|
| Primary Accession | Q8IYB7 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 6C7B2 |
| Isotype | IgG1 |
| Calculated MW | 99.3kDa |
| Description | The protein encoded by this gene is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene. |
| Immunogen | Purified recombinant fragment of human DIS3L2 (AA: 27-250) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Gene ID | 129563 |
|---|---|
| Other Names | DIS3-like exonuclease 2 {ECO:0000255|HAMAP-Rule:MF_03045}, hDIS3L2, 3.1.13.- {ECO:0000255|HAMAP-Rule:MF_03045}, DIS3L2 {ECO:0000255|HAMAP-Rule:MF_03045}, FAM6A |
| Dilution | E~~1/10000 WB~~1/500 - 1/2000 FC~~1/200 - 1/400 IHC~~1/200 - 1/1000 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DIS3L2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DIS3L2 {ECO:0000255|HAMAP-Rule:MF_03045} |
|---|---|
| Synonyms | FAM6A |
| Function | 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. |
| Cellular Location | Cytoplasm. Cytoplasm, P-body |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. ;
References
1. Nat Rev Mol Cell Biol. 2013 Jun;14(6):328. 2. Nat Genet. 2012 Feb 5;44(3):277-84.
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