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IGFBP7 Antibody

Purified Mouse Monoclonal Antibody

     
  • E - IGFBP7 Antibody AO1866a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - IGFBP7 Antibody AO1866a
    Figure 1: Western blot analysis using IGFBP7 mAb against human IGFBP7 recombinant protein. (Expected MW is 36 kDa)
  • WB - IGFBP7 Antibody AO1866a
    Figure 2: Western blot analysis using IGFBP7 mAb against HEK293 (1) and IGFBP7 (AA: 52-156)-hIgGFc transfected HEK293 (2) cell lysate.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q16270
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 5A4A9
Isotype IgG1
Calculated MW 29.1kDa
Description This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307).
Immunogen Purified recombinant fragment of human IGFBP7 (AA: 52-156) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 3490
Other Names Insulin-like growth factor-binding protein 7, IBP-7, IGF-binding protein 7, IGFBP-7, IGFBP-rP1, MAC25 protein, PGI2-stimulating factor, Prostacyclin-stimulating factor, Tumor-derived adhesion factor, TAF, IGFBP7, MAC25, PSF
Dilution E~~1/10000
WB~~1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIGFBP7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IGFBP7
Synonyms MAC25, PSF
Function Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.
Cellular Location Secreted.
Research Areas
Citations (0)

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Background

This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). ;

References

1. Sci Signal. 2012 Dec 18;5(255):ra92. 2. Cancer Biol Ther. 2012 Feb 1;13(3):148-55.

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$ 385.00
Cat# AO1866a
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