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CD93 Antibody

Purified Mouse Monoclonal Antibody

     
  • E - CD93 Antibody AO1872a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

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  • WB - CD93 Antibody AO1872a
    Figure 1: Western blot analysis using CD93 mAb against human CD93 recombinant protein. (Expected MW is 31.7 kDa)
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  • WB - CD93 Antibody AO1872a
    Figure 2: Western blot analysis using CD93 mAb against HEK293 (1) and CD93 (AA: 474-535)-hIgGFc transfected HEK293 (2) cell lysate.
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  • IF - CD93 Antibody AO1872a
    Figure 3: Immunofluorescence analysis of Hela cells using CD93 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
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  • FC - CD93 Antibody AO1872a
    Figure 4: Flow cytometric analysis of HepG2 cells using CD93 mouse mAb (green) and negative control (red).
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  • IHC - CD93 Antibody AO1872a
    Figure 5: Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using CD93 mouse mAb with DAB staining.
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  • SPECIFICATION
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, FC, ICC, E
Primary Accession Q9NPY3
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1A10E10
Isotype IgG1
Calculated MW 68.6kDa
Description The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton.
Immunogen Purified recombinant fragment of human CD93 (AA: 474-535) expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 22918
Other Names Complement component C1q receptor, C1q/MBL/SPA receptor, C1qR, C1qR(p), C1qRp, CDw93, Complement component 1 q subcomponent receptor 1, Matrix-remodeling-associated protein 4, CD93, CD93, C1QR1, MXRA4
Dilution E~~1/10000
WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCD93 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD93
Synonyms C1QR1, MXRA4
Function Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.
Cellular Location Membrane; Single-pass type I membrane protein.
Tissue Location Highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils. Not expressed in cells of lymphoid origin
Research Areas
Citations (0)
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Background

The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3. ; ; ;

References

1. PLoS One. 2012;7(12):e51647. 2. J Clin Immunol. 2010 Sep;30(5):723-33.

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$ 385.00
Cat# AO1872a
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Availability: 7-10 days
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