|Application ||WB, IHC, FC, ICC, E|
|Description||The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene.|
|Immunogen||Purified recombinant fragment of human PLIN2 (AA: 286-437) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Other Names||Perilipin-2, Adipophilin, Adipose differentiation-related protein, ADRP, PLIN2, ADFP|
WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PLIN2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in development and maintenance of adipose tissue.|
|Cellular Location||Membrane; Peripheral membrane protein.|
|Tissue Location||Milk lipid globules.|
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This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. ;
1. Am J Physiol Endocrinol Metab. 2012 Nov 1;303(9):E1158-65. 2. Exp Physiol. 2012 Aug;97(8):970-80.
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