|Application ||WB, IHC, FC, E|
|Description||This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.|
|Immunogen||Purified recombinant fragment of human B2M (AA: 21-100) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide.|
|Other Names||Beta-2-microglobulin, Beta-2-microglobulin form pI 5.3, B2M|
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||B2M Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.|
|Cellular Location||Secreted. Note=Detected in serum and urine|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. ;
1. Cancer Immunol Immunother. 2012 Sep;61(9):1359-71. 2. Lupus. 2012 Sep;21(10):1098-104.
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