|Application ||WB, IHC, FC, ICC, E|
|Description||This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.|
|Immunogen||Purified recombinant fragment of human B2M (AA: 21-100) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide.|
|Other Names||Beta-2-microglobulin, Beta-2-microglobulin form pI 5.3, B2M|
WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||B2M Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.|
|Cellular Location||Secreted. Note=Detected in serum and urine|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. ; ; ; ; ;
1. Cancer Immunol Immunother. 2012 Sep;61(9):1359-71. 2. Lupus. 2012 Sep;21(10):1098-104.
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