|Application ||WB, IHC, FC, E|
|Description||The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth.|
|Immunogen||Purified recombinant fragment of human MSTN (AA:24-266) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide.|
|Other Names||Growth/differentiation factor 8, GDF-8, Myostatin, MSTN, GDF8|
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MSTN Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts specifically as a negative regulator of skeletal muscle growth.|
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This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus. ; ; ;
1. Eur J Endocrinol. 2012 Dec;167(6):873-80. 2. Biochem J. 2012 Aug 15;446(1):23-36.
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