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DSG3 Antibody

Purified Mouse Monoclonal Antibody

  • E - DSG3 Antibody AO1926a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - DSG3 Antibody AO1926a
    Figure 1: Western blot analysis using DSG3 mAb against human DSG3 (AA: 55-159) recombinant protein. (Expected MW is 37.5 kDa)
  • WB - DSG3 Antibody AO1926a
    Figure 2: Western blot analysis using DSG3 mAb against HEK293 (1) and DSG3 (AA: 55-159)-hIgGFc transfected HEK293 (2) cell lysate.
  • WB - DSG3 Antibody AO1926a
    Figure 3: Western blot analysis using DSG3 mouse mAb against A431 cell lysate.
  • FC - DSG3 Antibody AO1926a
    Figure 4: Flow cytometric analysis of A431 cells using DSG3 mouse mAb (green) and negative control (red).
  • IHC - DSG3 Antibody AO1926a
    Figure 5: Immunohistochemical analysis of paraffin-embedded esophageal cancer tissues using DSG3 mouse mAb with DAB staining.
  • IHC - DSG3 Antibody AO1926a
    Figure 6: Immunohistochemical analysis of paraffin-embedded esophageal tissues using DSG3 mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P32926
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 6G2C11
Isotype IgG1
Calculated MW 107.5kDa
Description Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.
Immunogen Purified recombinant fragment of human DSG3 (AA: 55-159) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide.
Additional Information
Gene ID 1830
Other Names Desmoglein-3, 130 kDa pemphigus vulgaris antigen, PVA, Cadherin family member 6, DSG3, CDHF6
Dilution E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDSG3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DSG3
Synonyms CDHF6
Function Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Cellular Location Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome
Tissue Location Epidermis, tongue, tonsil, esophagus and carcinomas
Research Areas
Citations (0)

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The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. ; ;


1. J Dermatol Sci. 2012 Feb;65(2):102-9. 2. Am J Pathol. 2009 May;174(5):1629-37.

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$ 385.00
Cat# AO1926a
(40 western blots)
Availability: 7-10 days
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