|Application ||WB, FC, E|
|Description||Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s|
|Immunogen||Purified recombinant fragment of human PLA2G12A (AA: 21-189) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide.|
|Other Names||Group XIIA secretory phospholipase A2, GXII sPLA2, sPLA2-XII, 220.127.116.11, Phosphatidylcholine 2-acylhydrolase 12A, PLA2G12A, PLA2G12|
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
|Precautions||PLA2G12A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl- phosphatidylcholine or -phosphatidylethanolamine.|
|Cellular Location||Secreted. Cytoplasm|
|Tissue Location||Abundantly expressed in heart, skeletal muscle, kidney, liver and pancreas|
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The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. ; ;
1. J Biol Chem. 2003 Mar 21;278(12):10657-67. 2. Biochemistry. 2003 Oct 7;42(39):11494-503.
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