|Application ||WB, IHC, FC, E|
|Description||The protein encoded by this gene is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. Family members play important roles in pain perception, arterial pressure regulation, phosphate metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein. This gene is expressed mainly in testis with weak expression in the brain, kidney, and heart.|
|Immunogen||Purified recombinant fragment of human MMEL1 (AA: 1-107) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide.|
|Other Names||Membrane metallo-endopeptidase-like 1, 188.8.131.52, Membrane metallo-endopeptidase-like 2, NEP2(m), Neprilysin II, NEPII, Neprilysin-2, NEP2, NL2, Membrane metallo-endopeptidase-like 1, soluble form, Neprilysin-2 secreted, NEP2(s), MMEL1, MELL1, MMEL2, NEP2|
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MMEL1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||MELL1, MMEL2, NEP2|
|Function||Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond (By similarity).|
|Cellular Location||Membrane; Single-pass type II membrane protein. Secreted. Note=A secreted form produced by proteollytic cleavage also exists.|
|Tissue Location||Predominantly expressed in testis. Weakly expressed in brain, kidney and heart|
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The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. ; ;
1. Genes Immun. 2010 Dec;11(8):660-4.2. Ann Rheum Dis. 2011 Oct;70(10):1793-7.
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