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MMEL1 Antibody

Purified Mouse Monoclonal Antibody

  • E - MMEL1 Antibody AO1937a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - MMEL1 Antibody AO1937a
    Figure 1: Western blot analysis using MMEL1 mAb against human MMEL1 (AA: 1-107) recombinant protein. (Expected MW is 37 kDa)
  • WB - MMEL1 Antibody AO1937a
    Figure 2: Western blot analysis using MMEL1 mAb against HEK293 (1) and MMEL1 (AA: 1-107)-hIgGFc transfected HEK293 (2) cell lysate.
  • FC - MMEL1 Antibody AO1937a
    Figure 3: Flow cytometric analysis of Hela cells using MMEL1 mouse mAb (green) and negative control (red).
  • IHC - MMEL1 Antibody AO1937a
    Figure 4: Immunohistochemical analysis of paraffin-embedded ovarian cancer tissues using MMEL1 mouse mAb with DAB staining.
  • IHC - MMEL1 Antibody AO1937a
    Figure 5: Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using MMEL1 mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q495T6
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2D2H5
Isotype IgG1
Calculated MW 89.4kDa
Description The protein encoded by this gene is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. Family members play important roles in pain perception, arterial pressure regulation, phosphate metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein. This gene is expressed mainly in testis with weak expression in the brain, kidney, and heart.
Immunogen Purified recombinant fragment of human MMEL1 (AA: 1-107) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide.
Additional Information
Gene ID 79258
Other Names Membrane metallo-endopeptidase-like 1,, Membrane metallo-endopeptidase-like 2, NEP2(m), Neprilysin II, NEPII, Neprilysin-2, NEP2, NL2, Membrane metallo-endopeptidase-like 1, soluble form, Neprilysin-2 secreted, NEP2(s), MMEL1, MELL1, MMEL2, NEP2
Dilution E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMMEL1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MMEL1
Synonyms MELL1, MMEL2, NEP2
Function Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond (By similarity).
Cellular Location Membrane; Single-pass type II membrane protein. Secreted. Note=A secreted form produced by proteollytic cleavage also exists.
Tissue Location Predominantly expressed in testis. Weakly expressed in brain, kidney and heart
Research Areas
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The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. ; ;


1. Genes Immun. 2010 Dec;11(8):660-4.2. Ann Rheum Dis. 2011 Oct;70(10):1793-7.

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$ 325.00
Cat# AO1937a
(40 western blots)
Availability: 7-10 days
Bulk Size
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