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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PPP1CB Antibody   

PPP1CB Antibody

Purified Mouse Monoclonal Antibody

  • E - PPP1CB Antibody AO1939a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - PPP1CB Antibody AO1939a
    Figure 1: Western blot analysis using PPP1CB mAb against human PPP1CB (AA: 174-327) recombinant protein. (Expected MW is 43.2 kDa)
  • WB - PPP1CB Antibody AO1939a
    Figure 2: Western blot analysis using PPP1CB mAb against HEK293 (1) and PPP1CB (AA: 174-327)-hIgGFc transfected HEK293 (2) cell lysate.
  • WB - PPP1CB Antibody AO1939a
    Figure 3: Western blot analysis using PPP1CB mouse mAb against Jurkat (1), A431 (2), Hela (3), HepG2 (4), HEK293 (5), MCF-7 (6) cell lysate.
  • IF - PPP1CB Antibody AO1939a
    Figure 4: Immunofluorescence analysis of MCF-7 cells using PPP1CB mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Secondary antibody from Fisher (Cat#: 35503)
  • FC - PPP1CB Antibody AO1939a
    Figure 5: Flow cytometric analysis of Jurkat cells using PPP1CB mouse mAb (green) and negative control (red).
  • IHC - PPP1CB Antibody AO1939a
    Figure 6: Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using PPP1CB mouse mAb with DAB staining.
  • IHC - PPP1CB Antibody AO1939a
    Figure 7: Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using PPP1CB mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P62140
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 8A7C7
Isotype IgG1
Calculated MW 37.2kDa
Description The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed
Immunogen Purified recombinant fragment of human PPP1CB (AA: 174-327) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide.
Additional Information
Gene ID 5500
Other Names Serine/threonine-protein phosphatase PP1-beta catalytic subunit, PP-1B, PPP1CD,,, PPP1CB
Dilution E~~1/10000
WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPPP1CB Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T- cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).
Cellular Location Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles
Research Areas
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This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of mesenchymal tissues. ; ;


1. J Biol Chem. 2011 Sep 23;286(38):32931-6.2. Mol Biol Cell. 2010 Dec;21(24):4409-17.

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$ 325.00
Cat# AO1939a
(40 western blots)
Availability: 7-10 days
Bulk Size
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