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MEN1 Antibody

Purified Mouse Monoclonal Antibody

  • E - MEN1 Antibody AO1941a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - MEN1 Antibody AO1941a
    Figure 1: Western blot analysis using MEN1 mAb against human MEN1 (AA: 392-554) recombinant protein. (Expected MW is 43.3 kDa)
  • WB - MEN1 Antibody AO1941a
    Figure 2: Western blot analysis using MEN1 mAb against HEK293 (1) and MEN1 (AA: 392-554)-hIgGFc transfected HEK293 (2) cell lysate.
  • FC - MEN1 Antibody AO1941a
    Figure 3: Flow cytometric analysis of Hela cells using MEN1 mouse mAb (green) and negative control (red).
  • IHC - MEN1 Antibody AO1941a
    Figure 4: Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using MEN1 mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O00255
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 7D3E10
Isotype IgG1
Calculated MW 68kDa
Description This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants.
Immunogen Purified recombinant fragment of human MEN1 (AA: 392-554) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide.
Additional Information
Gene ID 4221
Other Names Menin, MEN1, SCG2
Dilution E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMEN1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MEN1
Synonyms SCG2
Function Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair.
Cellular Location Nucleus. Note=Concentrated in nuclear body-like structures. Relocates to the nuclear matrix upon gamma irradiation
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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The innate immune system confers host defense against viral and microbial infection, and TRAFD1 is a negative feedback regulator that controls excessive immune responses ; ;


1. Clinics (Sao Paulo). 2012;67 Suppl 1:49-56.2. World J Surg Oncol. 2011 Jan 25;9:6.

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$ 385.00
Cat# AO1941a
(40 western blots)
Availability: 7-10 days
Bulk Size
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