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FTL Antibody

Purified Mouse Monoclonal Antibody

  • E - FTL Antibody AO1942a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - FTL Antibody AO1942a
    Figure 1: Western blot analysis using FTL mAb against human FTL (AA: FULL(1-175)) recombinant protein. (Expected MW is 45.5 kDa)
  • WB - FTL Antibody AO1942a
    Figure 2: Western blot analysis using FTL mAb against HEK293 (1) and FTL (AA: FULL(1-175))-hIgGFc transfected HEK293 (2) cell lysate.
  • WB - FTL Antibody AO1942a
    Figure 3: Western blot analysis using FTL mouse mAb against HepG2 (1), K562 (2) cell lysate.
  • FC - FTL Antibody AO1942a
    Figure 4: Flow cytometric analysis of HepG2 cells using FTL mouse mAb (green) and negative control (red).
  • IHC - FTL Antibody AO1942a
    Figure 5: Immunohistochemical analysis of paraffin-embedded ovarian cancer tissues using FTL mouse mAb with DAB staining.
  • IHC - FTL Antibody AO1942a
    Figure 6: Immunohistochemical analysis of paraffin-embedded esophageal tissues using FTL mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P02792
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 6E10E4
Isotype IgG1
Calculated MW 20kDa
Description This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes.
Immunogen Purified recombinant fragment of human FTL (AA: FULL(1-175)) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide.
Additional Information
Gene ID 2512
Other Names Ferritin light chain, Ferritin L subunit, FTL
Dilution E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFTL Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FTL
Function Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
Research Areas
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C17orf53 (chromosome 17 open reading frame 53) is a 647 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17. ; ; ;


1. Free Radic Biol Med. 2012 May 1;52(9):1692-7.2. Neurobiol Dis. 2010 Jan;37(1):77-85.

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$ 385.00
Cat# AO1942a
(40 western blots)
Availability: 7-10 days
Bulk Size
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