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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   RAB27A Antibody   

RAB27A Antibody

Purified Mouse Monoclonal Antibody

  • E - RAB27A Antibody AO1944a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - RAB27A Antibody AO1944a
    Figure 1: Western blot analysis using RAB27A mAb against human RAB27A (AA: FULL(1-221)) recombinant protein. (Expected MW is 50.8 kDa)
  • WB - RAB27A Antibody AO1944a
    Figure 2: Western blot analysis using RAB27A mAb against HEK293 (1) and RAB27A (AA: FULL(1-221))-hIgGFc transfected HEK293 (2) cell lysate.
  • IHC - RAB27A Antibody AO1944a
    Figure 3: Immunohistochemical analysis of paraffin-embedded prostate cancer tissues using RAB27A mouse mAb with DAB staining.
  • IHC - RAB27A Antibody AO1944a
    Figure 4: Immunohistochemical analysis of paraffin-embedded liver cancer tissues using RAB27A mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P51159
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 7D7C9
Isotype IgG2b
Calculated MW 24.9kDa
Description The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.
Immunogen Purified recombinant fragment of human RAB27A (AA: FULL(1-221)) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide.
Additional Information
Gene ID 5873
Other Names Ras-related protein Rab-27A, Rab-27, GTP-binding protein Ram, RAB27A, RAB27
Dilution E~~1/10000
WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRAB27A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RAB27A
Synonyms RAB27
Function Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.
Cellular Location Membrane; Lipid-anchor. Melanosome. Late endosome. Lysosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes to endosomal exocytic vesicles
Tissue Location Found in all the examined tissues except in brain. Low expression was found in thymus, kidney, muscle and placenta. Detected in melanocytes, and in most tumor cell lines examined. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells.
Research Areas
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C17orf53 (chromosome 17 open reading frame 53) is a 647 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17. ; ;


1. PLoS One. 2012;7(7):e41160.2. J Biol Chem. 2011 Feb 18;286(7):5375-82.

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$ 385.00
Cat# AO1944a
(40 western blots)
Availability: 7-10 days
Bulk Size
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