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RPS6KA2 Antibody

Purified Mouse Monoclonal Antibody

  • E - RPS6KA2 Antibody AO1964a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - RPS6KA2 Antibody AO1964a
    Figure 1: Western blot analysis using RPS6KA2 mAb against human RPS6KA2 (AA: 415-734) recombinant protein. (Expected MW is 62 kDa)
  • WB - RPS6KA2 Antibody AO1964a
    Figure 2: Western blot analysis using RPS6KA2 mAb against HEK293 (1) and RPS6KA2 (AA: 415-734)-hIgGFc transfected HEK293 (2) cell lysate.
  • WB - RPS6KA2 Antibody AO1964a
    Figure 3: Western blot analysis using RPS6KA2 mouse mAb against Hela (1), A431 (2), HEK293 (3), Jurkat (4), HepG2 (5), MCF-7 (6), NIH/3T3 (7) cell lysate.
  • IF - RPS6KA2 Antibody AO1964a

    Figure 4:Immunofluorescence analysis of A431 cells using RPS6KA2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)

  • FC - RPS6KA2 Antibody AO1964a
    Figure 5: Flow cytometric analysis of Hela cells using RPS6KA2 mouse mAb (green) and negative control (red).
  • IHC - RPS6KA2 Antibody AO1964a
    Figure 6: Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using RPS6KA2 mouse mAb with DAB staining.
  • IHC - RPS6KA2 Antibody AO1964a
    Figure 7: Immunohistochemical analysis of paraffin-embedded lung cancer tissues using RPS6KA2 mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q15349
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Clone Names 3C4C8
Isotype IgG1
Calculated MW 83.2kDa
Description This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Immunogen Purified recombinant fragment of human RPS6KA2 (AA: 415-734) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide.
Additional Information
Gene ID 6196
Other Names Ribosomal protein S6 kinase alpha-2, S6K-alpha-2,, 90 kDa ribosomal protein S6 kinase 2, p90-RSK 2, p90RSK2, MAP kinase-activated protein kinase 1c, MAPK-activated protein kinase 1c, MAPKAP kinase 1c, MAPKAPK-1c, Ribosomal S6 kinase 3, RSK-3, pp90RSK3, RPS6KA2, MAPKAPK1C, RSK3
Dilution E~~1/10000
WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRPS6KA2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RPS6KA2
Synonyms MAPKAPK1C, RSK3
Function Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.
Cellular Location Nucleus. Cytoplasm
Tissue Location Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate
Research Areas
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Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18AE family of ribosomal proteins that is a component of the 60S subunit. The encoded protein may play a role in viral replication by interacting with the hepatitis C virus internal ribosome entry site (IRES). This gene is co-transcribed with the U68 snoRNA, located within the third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. ; ;


1. Oncogene. 2007 Feb 1;26(5):683-700. 2. Exp Mol Med. 2003 Oct 31;35(5):365-70.

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$ 385.00
Cat# AO1964a
(40 western blots)
Availability: 7-10 days
Bulk Size
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