|Application ||WB, FC, E|
|Description||The protein encoded by this gene is a component of the pre-mRNA-processing factor 19-cell division cycle 5-like (PRP19-CDC5L) protein complex, which activates pre-mRNA splicing and is an integral part of the spliceosome. The encoded protein is also a nuclear localization sequence binding protein, and binds to activation-induced deaminase and is important for antibody diversification. This gene may also be associated with the development of obesity. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome.|
|Immunogen||Purified recombinant fragment of human CTNNBL1 (AA: 390-557) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide.|
|Other Names||Beta-catenin-like protein 1, Nuclear-associated protein, NAP, Testis development protein NYD-SP19, CTNNBL1, C20orf33|
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CTNNBL1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.|
|Cellular Location||Isoform 1: Nucleus.|
|Tissue Location||Widely expressed with highest levels in skeletal muscle, placenta, heart, spleen, testis and thyroid|
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There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive brush-border enzyme. This enzyme is upregulated during small intestinal epithelial cell differentiation.
1. Mol Psychiatry. 2013 Feb;18(2):255-63.2. BMC Med Genet. 2009 Feb 26;10:17.
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