|Application ||WB, FC, E|
|Description||This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene.|
|Immunogen||Purified recombinant fragment of human CSNK2B (AA: FULL(1-215)) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide.|
|Other Names||Casein kinase II subunit beta, CK II beta, Phosvitin, Protein G5a, CSNK2B, CK2N, G5A|
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CSNK2B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.|
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T protein p53 binding protein 1 may have a role in checkpoint signaling during mitosis,enhance TP53-mediated transcriptional activation and play a role in the response to DNA damage. ;
1. Nan Fang Yi Ke Da Xue Xue Bao. 2012 Oct;32(10):1491-4.2. Am J Pathol. 2009 Jan;174(1):287-96.
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