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APBB1IP Antibody

Purified Mouse Monoclonal Antibody

  • E - APBB1IP Antibody AO1989a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - APBB1IP Antibody AO1989a
    Figure 1: Western blot analysis using APBB1IP mAb against human APBB1IP (AA: 1-151) recombinant protein. (Expected MW is 42.1 kDa)
  • WB - APBB1IP Antibody AO1989a
    Figure 2: Western blot analysis using APBB1IP mAb against HEK293 (1) and APBB1IP (AA: 1-151)-hIgGFc transfected HEK293 (2) cell lysate.
  • FC - APBB1IP Antibody AO1989a
    Figure 3: Flow cytometric analysis of Hela cells using APBB1IP mouse mAb (green) and negative control (red).
  • IHC - APBB1IP Antibody AO1989a
    Figure 4: Immunohistochemical analysis of paraffin-embedded lymph tissues using APBB1IP mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q7Z5R6
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 7E7D12
Isotype IgG1
Calculated MW 73.2kDa
Description APBB1IP (amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein) is a protein-coding gene. Diseases associated with APBB1IP include alzheimer's disease, and melanoma, and among its related super-pathways are p130Cas linkage to MAPK signaling for integrins and Platelet Aggregation (Plug Formation). GO annotations related to this gene include phospholipid binding. An important paralog of this gene is GRB7.
Immunogen Purified recombinant fragment of human APBB1IP (AA: 1-151) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide.
Additional Information
Gene ID 54518
Other Names Amyloid beta A4 precursor protein-binding family B member 1-interacting protein, APBB1-interacting protein 1, Proline-rich EVH1 ligand 1, PREL-1, Proline-rich protein 73, Rap1-GTP-interacting adapter molecule, RIAM, Retinoic acid-responsive proline-rich protein 1, RARP-1, APBB1IP, PREL1, RARP1, RIAM
Dilution E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAPBB1IP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms PREL1, RARP1, RIAM
Function Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin- induced promoter activities through AP1 and SRE. Mediates Rap1- induced adhesion.
Cellular Location Cell membrane; Peripheral membrane protein. Cell projection, lamellipodium. Cell junction, focal adhesion Cytoplasm, cytoskeleton. Note=Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F- actin at the leading edge. At the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns(5)P and PtdIns(3)P. This binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases (By similarity).
Tissue Location Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes
Research Areas
Citations (0)

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ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. ;


1. Cell Mol Life Sci. 2013 Jul;70(13):2395-410.2. J Biol Chem. 2011 May 27;286(21):18492-504.

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$ 385.00
Cat# AO1989a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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